The result of IF detection showed that the apoptosis level of podocytes in the kidney tissue of DN model mice is increased, and compared with control db/db mice, the fluorescence expression intensity of podocyte marker nephrin in the kidney tissue of db/db mice treated with YSHS granule increased, while the fluorescence expression intensity of cleaved caspase-3 in nephrin + cells decreased in a dose-dependent manner (Figure 3). This evidence concerns the gene CASP3 and liver dysplastic nodule.