In HF mouse models induced by CAL, after the intraperitoneal injection of YQFM (0.13 g/kg, 0.26 g/kg, 0.53 g/kg) for 14 days, the results showed that the levels of serum creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), interleukin-6 (IL-6), troponin, myosin, and myoglobin were down-regulated, and the omentin level elevated. The gene discussed is IL6; the disease is hydrops fetalis.