PCSK9 and musculoskeletal system disorder: Just as musculoskeletal disorders are more common and more likely to induce drug discontinuation in women over 65 than in younger men (Hopewell et al., 2012; Karalis et al., 2016; Cangemi et al., 2017), it is urgent to clarify whether specific high-risk subgroups exist for PCSK9 inhibitors.