Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular signaling pathways that is related to cell proliferation, motility, survival and apoptosis of cancer cells (Katso et al., 2001; Engelman et al., 2006). The gene discussed is AKT1; the disease is cancer.