Through comparing differentially expressed circRNAs in bone marrow mononuclear cells between EMI-AML and non-EMI AML patients, they found that seven target genes of 17 circRNAs (LRRK1, PLXNB2, OLFML2A, LYPD5, APOL3, ZNF511, and ASB2) revealed a poor prognosis (Lv et al., 2018) (Figure 3B). This evidence concerns the gene LRRK1 and acute myeloid leukemia.