ACTC1 and central nervous system cancer: Wu et al. (2021) found that the regulation of ITGB1 expression promotes progression, suggesting an essential role for ITGB1 in glioblastoma. Andersson et al. (2010) demonstrated that regulation of the EGFR pathway is involved in glioblastoma progression and that specific genotypes of the EGFR gene may be associated with glioblastoma risk. According to Ohtaki et al. (2017), ACTC1 is as an independent prognostic and aggressive marker of gliomas. In addition, Wu et al. (2022) demonstrated that CXCR4 promotes the proliferation of GICs through the KLF5/BCL2L12-dependent pathway.