AKT1 and early-onset autosomal dominant Alzheimer disease: DO enrichment analyses were mainly enriched in musculoskeletal system cancer, connective tissue cancer, non-small cell lung carcinoma, bone cancer, female reproductive organ cancer, and breast cancer; pathways related to neurodegeneration-multiple diseases, Alzheimer disease, PI3K-Akt signaling pathway, lipid and atherosclerosis, Epstein-Barr virus infection were enriched according to KEGG analysis.