After the knockdown of TMEM161B-AS1, hsa-miR-27a-3p can downregulate the expression of FANCD2 and CD44, inhibit the proliferation, migration and invasion of U87 and U251 cells, promote cell apoptosis and ferroptosis, and downregulate lncRNA TMEM161B-AS1; moreover, overexpression of hsa-miR-27a-3p can downregulate the expression of FANCD2 and CD44 and inhibit glioblastoma growth in nude mice (Zhao et al., 2020; Jiang et al., 2021). Here, CD44 is linked to glioblastoma.