Indeed, numerous reviews have showed evidence on PDE-mediated implications in such diseases, as cancer (Peng et al., 2018), neurologic (Halene and Siegel, 2007; Nthenge-Ngumbau and Mohanakumar, 2018; Gurney, 2019), inflammatory (Page and Spina, 2011), pulmonary (Fan Chung, 2006; Mokry et al., 2018; Joskova et al., 2020; Kawamatawong, 2021; Mokra and Mokry, 2021), pediatric (Mokra et al., 2018), and cardiovascular disorders (Ravipati et al., 2007), among others. This evidence concerns the gene ALDH7A1 and cancer.