Li et al. (2020e) found that in papillary thyroid cancer, propofol decreased HMGB1 expression and inhibited tumor progression through downregulation of ANRIL. Jia et al. (2017) found that propofol could down-regulate LPS-stimulated HMGB1 expression in RAW 264.7 cell supernatants and reduce the releasing of LPS-stimulated IL-6, IL-8, and TNF-α. This evidence concerns the gene HMGB1 and neoplasm.