Tregs play important protective roles in limiting autoimmune disorders (Tamosiuniene et al., 2018; Goodman et al., 2020), but functional Tregs are susceptible to both epigenetic alteration of the usually-expressed FOXP3 gene (Shu et al., 2017) and impaired estrogen signaling (Goodman et al., 2020, 2014), which may impair immunity and increase susceptibility to autoimmune diseases. Here, FOXP3 is linked to autoimmune disease.