REEP3 and depressive symptom measurement: To our knowledge, out of these predicted targets, only three [i.e., muscleblind like splicing regulator 1 (MBNL1), receptor accessory protein 3 (REEP3), retinoic acid receptor beta (RARB)] have previously been reported in the context of depression or depression-like phenotypes in the literature and none were described to be associated with suicidality (65–68).