DLL1 and neurodevelopmental disorder: Barhoumi et al. (2019) reported two affected individuals (boys) showing features such as scoliosis, fused thoracic spines (T4–T5, T6–T8, and T11–T12), and multiple spine deformities. The whole-exome sequence analysis of these patients revealed a homozygous missense mutation (c.1534G>A; p. Gly512Arg) in exon 9 of the DLL1 gene. In addition, 14 patients from unrelated families had neurodevelopmental disorders along with other brain abnormalities. The sequence analysis of these patients revealed the heterozygous mutations in the DLL1 gene (Fischer-Zirnsak et al., 2019).