The mutations in these genes such as LFNG, DLL3, and MESP2 have been shown to be associated with the abnormal molecular oscillations leading to the development of congenital vertebral malformations, that is, recessive spondylocostal dysostosis (SCDO) (Dequéant et al., 2006; Goldbeter and Pourquié, 2008). This evidence concerns the gene MESP2 and spondylocostal dysostosis.