Neurodegenerative diseases, such as Huntington’s Disease (HD) and possibly Alzheimer’s Disease (AD), exhibit alterations in NKCC1 and KCC2 expression that resemble immature neural circuits (Tang, 2020; Dargaei et al., 2018; Yin et al., 2019/01; Lam et al., 2022; Virtanen et al., 2021). The gene discussed is SLC12A5; the disease is Alzheimer disease.