MAPT and frontotemporal dementia: Recently, significant phenotypic overlap between TS and frontotemporal dementia (FTD) has also been described; this overlap includes TAND-associated cognitive-behavioral alterations, as well as clinical biomarkers, such as phosphorylated tau (Olney et al., 2017; Liu et al., 2020a; Alquezar et al., 2021; Liu et al., 2022).