SLC12A5 and frontotemporal dementia: Due to the NKCC1:KCC2 regulation of synapse formation and function, GABA-mediated depolarization could contribute to the observed increase in neuronal excitability in neurodegenerative disorders, including FTD (Wishart et al., 2006; Clare et al., 2010; Beagle et al., 2015; Cepeda et al., 2019; Subramanian et al., 2020; Targa Dias Anastacio et al., 2022).