Some studies have shown that UBE2S promotes the metastasis of lung adenocarcinoma cells by activating NF- κ B signal transduction, while other studies have shown that UBE2S regulates Wnt/β-catenin signal and promotes the progression of non-small cell lung cancer (Ho et al., 2021; Qin et al., 2020).In our predictive model, UBE2S is also an important factor in platinum resistance in patients with lung adenocarcinoma. This evidence concerns the gene UBE2S and lung adenocarcinoma.