Bing et al. found that there were significant differences in m7G mRNA modification in drug-resistant AML cells, and the low methylated m7G modification level was significantly enriched in ABC transporter related mRNA, suggesting that the down-regulation of m7G methylation can actively regulate ABC transporter related genes in AML cells, leading to drug resistance in AML (Zhang et al., 2022). This evidence concerns the gene ABCG2 and acute myeloid leukemia.