Chen et al., 2022 confirmed that m7G methyltransferase METTL1promotes the development of HNSCC by regulating PI3K/Akt signaling pathway, and changes the immune microenvironment and intercellular communication between HNSCC tumors and stroma. Epigenetic regulation plays a central role in the pathogenesis of sepsis (Binnie et al., 2020), but the role and mechanism of m7G in sepsis remain unclear. The gene discussed is AKT1; the disease is head and neck squamous cell carcinoma.