In addition to observing greater levels of gene expression variability across location in the RPE-choroid than expected, several disease-relevant genes known to play roles in various ocular disorders including TIMP3 [various retinopathies (Dewing et al., 2020)], ABCA4 [Stargardt disease (Walia and Fishman, 2009)], and TYRP1 [oculocutaneous albinism (Simeonov et al., 2013)], were found to be significantly differentially expressed by location. Here, TYRP1 is linked to retinal disorder.