Pathway analysis on these gene lists shows enrichment in the upregulated interactors for cell adhesion pathways (Figures 2A,C) and that downregulated interactors were highly enriched for Wnt signaling in kidney disease and the ErbB signaling pathway, both of which are heavily involved in tissue development, including ocular development (Figures 2B,D; Supplementary Figures S7C,D). This evidence concerns the gene EGFR and kidney disorder.