WFDC1 and age-related macular degeneration: As a serine protease inhibitor, mediator of endothelial cell migration and promoter of angiogenesis, its enrichment in the RPE and specifically, the macula, may suggest a role for WFDC1 in age-related macular degeneration (Zhu et al., 2021), in which neovascularization beneath the macula is characteristic (Radeke et al., 2007).