As shown in Figure 2, the pooled results of the stacked bar graph and Wilcoxon analyses on TCGA COAD/READ datasets revealed the stromal and immune scores; the infiltrations of several TME contents such as B cells, CD8+ T cells, M1 Macrophages, M2 Macrophages, NK cells and Tregs were lower at later stages of CRC. The gene discussed is CD8A; the disease is colorectal carcinoma.