Elevation of miR155-5p levels in nasal epithelial cells caused by enhanced TGF-β1 levels in CRSwNP patients could more efficiently target to SIRT1, participate in EMT progression in epithelial cells and affect the airway remodeling process in nasal tissue (Yang et al., 2020). This evidence concerns the gene SIRT1 and chronic rhinosinusitis with nasal polyps.