Furthermore, IL-4 suppresses the transcription of the IL-10 gene in response to HDAC11, the gene transcriptional repressor (Luo et al., 2017), thus significantly increasing the levels of miR-19a and IL-10 in DC cells of CRSwNP patients (Simpson et al., 2014). Here, IL4 is linked to chronic rhinosinusitis with nasal polyps.