SIRT1 and chronic rhinosinusitis with nasal polyps: EMT causes loss of cell connectivity and polarity in CRSwNP tissues, conversion of nasal epithelial cells to mesenchymal cell phenotypes, downregulation of epithelial markers expression such as e-cadherin and SIRT1 and upregulation of mesenchymal markers expression such as-SMA and MMP (Thiery et al., 2009).