The CRSwNP mainly showed Th2 cell inflammation, mainly involving the effects of IL-4, IL-5, and IL-13, accompanied by changes in IL-25, IL-33, TSLP and IgE levels, with eosinophil infiltration and nasal polyps phenomenon (Fossiez et al., 1996). The gene discussed is IL4; the disease is chronic rhinosinusitis with nasal polyps.