Similar to our results, others have shown that plasma from primary FSGS patients and rFSGS patients causes significant disorganization of the podocytes’ actin cytoskeleton.15, 16, 17 In contrary to other studies, however, we show that our actin cytoskeleton staining method can distinguish between CPF-mediated FSGS and other forms of NS, such as SRNS, MCNS, and MN. Here, NR5A2 is linked to lipoid nephrosis.