MAPT and Alzheimer disease: In addition to different types of neuropsychological scales that cannot avoid subjective bias from the operators, the current laboratory methods for AD diagnosis were mainly aimed at measuring Aβ deposition and tau hyperphosphorylation, such as measuring Aβ and tau in cerebrospinal fluid by ELISA, in the brains using MRI and PET (Frisoni et al., 2010; McKhann et al., 2011; Rice and Bisdas, 2017).