CRH and Alzheimer disease: The level of CRHBP-mediated corticotropin-releasing factor (CRF) was significantly decreased in the cortex and cerebrospinal fluid of AD patients (Bissette et al., 1985; May et al., 1987); therefore, downregulating CRHBP may increase the level of free CRF, which could be an attractive direction for the treatment of AD (Vandael and Gounko, 2019).