Cluster 1 displays a significant increase in T2DM vs. Ctrl but a decrease in T2DM-MCI vs. T2DM-nMCI (Figure 1C), including immune response-related proteins alpha-2-macroglobulin (A2M), myeloperoxidase (MPO), gelsolin (GSN), gluconeogenesis/glycolysis-related proteins glucose-6-phosphate isomerase (GPI), and fructose-1,6-bisphosphatase 1 (FBP1) (Figure 1D). The gene discussed is A2M; the disease is type 2 diabetes mellitus.