ANGPT2 and neoplasm: This transition leads to the activation of many cytokines by matrix metalloproteinases or other proteinases, such as IL-8, VEGF, and angiopoietin 2 (ANGPT2), which promote tumor neovascularization (Pouyssegur et al., 2006; Vegran et al., 2011; Xiao et al., 2020).