Secondly, inhibition of MCTs, especially MCT4, can reduce the production of a large number of antioxidants in the hypoxic zone, such as glutathione or lactate, and prevent tumor cells from entering the G0 quiescent phase by affecting the AMPK pathway and the mammalian target of rapamycin (mTOR) pathway, thereby enhancing the effect of radiation therapy (Brandstetter et al., 2021). This evidence concerns the gene SLC16A3 and neoplasm.