The relative changes in the SCD1 and ACSL4 levels after MCT1-mediated lactate uptake suggest that the lactate-induced shifting in MUFAs and PUFAs production may act in concert to synergistically enhance the ferroptosis resistance in tumor cells by activating the AMPK-SREBP1-SCD1 pathway (Zhao et al., 2020). This evidence concerns the gene SREBF1 and neoplasm.