SLC16A1 and cancer: The inhibitory effect of BAY-8002 on MCT1 is 5 times that of MCT2, and there is no off-target effect on MCT4 (Quanz et al., 2018).7ACC2 inhibits lactate inflow, but does not inhibit lactate outflow from cancer cells expressing MCT1/4 (Draoui et al., 2014).