Li et al. found that SNHG16, a sponge of miRNA has-let-7b-5p, induced drug resistance in hepatocellular carcinoma by upregulating the expression of CDC25B and HMGA2, and that downregulation of SNHG16 led to apoptosis (Li et al., 2020). This evidence concerns the gene HMGA2 and hepatocellular carcinoma.