Rahim et al. Rahim et al. (2021) also find increased mitochondrial fission in cardiac tissues of CLP-induced sepsis mice, manifested as increased Drp1 content and decreased Mfn2 level; whereas melatonin improves SIMD prognosis by increasing Mfn2/Drp1 ratio. The gene discussed is MFN2; the disease is Sepsis.