Since mutations of the CHRNB2 gene are associated with autosomal dominant nocturnal frontal lobe epilepsy (Diaz-Otero et al., 2008), our data suggest that CHRNB2 may be involved in mechanisms leading to an increased risk of epilepsy in FXS. The gene discussed is CHRNB2; the disease is autosomal dominant nocturnal frontal lobe epilepsy.