Fmr1 KO mice recapitulate the main FXS phenotype and show susceptibility to audiogenic seizures (AGSs) caused by increased activity of glutamatergic neurons and decreased GABAergic transmission in the auditory pathways (Rotschafer and Razak, 2014; Rotschafer et al., 2015; Ethridge et al., 2017; Rotschafer and Cramer, 2017; Gonzalez et al., 2019). Here, FMR1 is linked to fragile X syndrome.