SPARC and cancer: An abnormal expression of SPARC proteins is found in human pathologies such as chronic inflammation (Riley and Bradshaw, 2020), fibrosis (Trombetta-Esilva and Bradshaw, 2012), rheumatoid arthritis (Sangaletti et al., 2021), kidney diseases (Bao et al., 2021), diabetes (Kos and Wilding, 2010), central nervous system diseases (Chen et al., 2020), cancer and cancer metastasis (Ribeiro et al., 2014; Said, 2016; Camacho et al., 2020).