CPEB4 and esophageal squamous cell carcinoma: cDOPEY2 serves as a protein scaffold to potentiate the interaction between the E3 ligase TRIM25 and cytoplasmic polyadenylation element binding protein (CPEB4), thereby promoting the ubiquitination and degradation of CPEB4 in esophageal squamous cell carcinoma (Liu et al., 2021).