HMGA1 and breast cancer: In particular, in the human TCam-2 cell line (a model of cisplatin resistant primary tumor of the testis), the antiproliferative and antimigratory activities of Met have been shown to intersect with the Hippo pathway (56), a newly discovered tumor suppressor cascade downstream of HMGA1, which is deregulated in several human cancers, including the malignant tumors of the breast (57).