A meta-analysis including 20 randomized clinical trials with total 1464 DN patients suggested that vitamin D supplement (calcitriol, alfacalcidol and vitamin D3) improved 24-hour urine protein and urine albumin excretion rate, as well as inflammatory indexes, such as hs-CRP, TNF-α and IL-6 (111). This evidence concerns the gene ALB and liver dysplastic nodule.