INS and type 1 diabetes mellitus: Currently, the standard method to identify individuals at risk for T1DM is to analyze the presence of autoantibodies against islet antigens, among them, against islet cells (ICA), glutamate decarboxylase (GADA), insulin (IAA), tyrosine phosphatases (IA-2 and IA-2β), and zinc transporter 8 (ZnT8) (7).