In our study, hsa-miR-26b-5p, hsa-let-7i-5p, hsa-miR-100-5p and hsa-miR-143-3p were found to be interacting with IGF1R and/or IGF1 gene, suggesting that these miRNAs might play a role in this insulin resistance metabolism, in addition to diabetic complications. The gene discussed is IGF1R; the disease is Insulin resistance.