Likewise, a study showed that K14–VEGFR-3–Ig(sR3) mice that expressed soluble VEGFR-3–Ig in the skin to scavenge VEGF-C were protected against HFD-induced insulin resistance and hepatic lipid accumulation, which was related to an increased M2/M1 macrophage ratio (72). Here, FLT4 is linked to Insulin resistance.