INS and type 2 diabetes mellitus: Even if new better OAD (e.g. sodium-glucose cotransporter 2 inhibitors) and injectable GLP-1RA are available, many patients eventually require and benefit from insulin therapy (4).However, initiating insulin is the most difficult step in the treatment of type 2 diabetes (T2D) because of clinical inertia, which is a common phenomenon all over the world (7, 8).