XDH and hyperuricemia: Decreases serum uric acid, serum urea nitrogen, serum xanthine oxidase (XOD), and hepatic XOD.Up-regulates UA excretion genes, such as ABCG2, OAT1, and NPT1.Down-regulates UA absorption gene URAT1 was down-regulated.Maintains intestinal flora stability, which is closely related to the regulation of hyperuricemia.