Increases hypoxanthine phosphate ribose transferase expression.Inhibits the uric acid synthesis by activating uric acid transporter.Inhibits NLRP3 inflammasome and TLR4/MyD88/NF-κB pathway.Regulates the composition and abundance of gut microbiota during hyperuricemia and renal inflammation. The gene discussed is TLR4; the disease is hyperuricemia.