BAT1 was identified as an anti-inflammatory gene through the modulation of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) in diabetes, Chagas cardiomyopathy, and Plasmodium vivax malaria. Here, DDX39B is linked to Chagas cardiomyopathy.