The expression heatmap of these 16 COL6A2-related immunostimulatory genes in glioma patients showed that CD274, IDO1, IL10, KDR, CD40, CD70, CD276, CXCL1, IL2RA, IL6R, TMEM173, TNFRSF14, TNFSF13, TNFSF14 and ULBP1 were highly expressed in the high-risk group, while in the low-risk group, TNFRSF13C was up-regulated (Figure 14A), indicating that the risk score of glioma had a prognostic value. This evidence concerns the gene IDO1 and central nervous system cancer.