Based on the literature survey, 42 out of 110 proteins were found to be differentially abundant in GBC at tissue level and 76 to be differentially abundant in plasma or plasma-derived EVs from GBC various cancers including GBC, while 16 of them were common across them and included HP, PKM, ANXA2, THBS1 (Figure 4, Table 2; Supplementary Table S2). This evidence concerns the gene ANXA2 and cancer.