After transfection with small interference RNA sh-circ_0007534, qRT-PCR and western blotting showed that compared with the sh-NC group, the level of GREM1 was downregulated, while the expression of miR-206 was upregulated and the tumor volume and weight were decreased in the subcutaneous tumor tissue of the sh-circ_0007534 group. The gene discussed is GREM1; the disease is neoplasm.