FZD7 and intrahepatic cholangiocarcinoma: Another study (41) indicated that circACTN4 is upregulated in intrahepatic cholangiocarcinoma by acting as a molecular sponge for miR-424-5p and interacting with YBX1 to transcriptionally activate FZD7, thereby promoting the proliferation and metastasis of intrahepatic cholangiocarcinoma.