CDKN2A and neoplasm: According to an article of Science, loss of functions of cyclin-dependent kinase inhibitor 2A (CDKN2A) could sensitize the copper-induced cell death by elesclomol and disulfiram-diethyldithiocarbamat (two structurally distinct copper-loaded ionophores), which meant that CDKN2A might inhibit cuproptosis and be a beneficial gene for tumor cell growth (8).