Chordoma tumors are known to overexpress multiple kinases (56) (included PDGFR-α, PDGFR-β, c-Kit, c-Met, pAKT, mTOR, HER2, VEGFR, and EGFR) which are involved in a multitude of cellular functions relevant to cancer pathogenesis. The gene discussed is ERBB2; the disease is cancer.