Other studies found that BC cells treated with LCA in vitro decreased the expression of nuclear factor-2 (NRF2) and increased the expression of Kelch-like ECH associating protein 1 (KEAP1), constitutive androstane receptor (CAR) and inducible nitric oxide synthase (iNOS) (108). This evidence concerns the gene NOS2 and Leber congenital amaurosis.