Moreover, the activation of Wnt signaling activates SIRT1 to interact with Dsh forming a complex that will phosphorylate and activate PI3K/AKT signaling pathway, that will also result in the translocation of β-catenin into the nucleus to activate its downstream targets promoting cell migration in colon and BC cells (24, 36, 37). The gene discussed is SIRT1; the disease is breast cancer.