The results demonstrated that the expression levels of TRADD, H2AC6, JMJD7-PLA2G4B, TRAF2, UCHL1, DAPK1, and RBCK1 are higher in the high-risk group than those in the low-risk group, suggesting that the high expression of these genes in COAD is associated with poor prognosis. Here, PLA2G4B is linked to colon adenocarcinoma.