Our results showed that TRAF2, RBCK1, JMJD7-PLA2G4B, and VDAC3 were upregulated, while UCHL1, DAPK1, and H2AC6 were downregulated significantly in the COAD samples compared with those in normal colon samples. The gene discussed is JMJD7; the disease is colon adenocarcinoma.