GPT and renal cell carcinoma: The mechanisms underlying the relationship between these inflammatory markers and RCC are not well-understood, but may involve neutrophils and platelet release of inflammatory cytokines and growth factors including the proangiogenic vascular angiogenic growth factor (VEGF), contributing to tumor invasion and metastasis reflected in NLR and PLR (10), and alterations in cellular metabolism and aerobic glycolysis associated with cell proliferation reflected in changes in AST and ALT activity (11, 12).