Firstly, the top 6 positively co-expressed genes of PSMD2 were identified by using Pearson correlation analysis, the results showed that the EIF4G1 (r=0.880, p<0.001), tubulin alpha 1c (TUBA1C) (r=0.810, p<0.001), leucine rich repeat containing 42 (LRRC42) (r=0.790, p<0.001), histone acetyltransferase 1 (HAT1) (r=0.780, p<0.001), YKT6 (r=0.780, p<0.001), DNA cross-link repair 1B (DCLRE1B) (r=0.780, p<0.001) are the top 6 co-expressed genes of PSMD2 in TCGA-BLCA cohort (Figures 5A–F). The gene discussed is LRRC42; the disease is bladder transitional cell carcinoma.