Moreover, cell assays were performed to verify the carcinogenesis of PSMD2 in human BCa cell lines, the findings showed that PSMD2 depletion can significantly inhibit the wound healing and colony formation ability of BCa cell lines, these results were consistent with previous researches that reported PSMD2 knockdown strongly depress the progression of lung adenocarcinomas, hepatocellular carcinoma and breast cancer (9, 22, 23). Here, PSMD2 is linked to lung adenocarcinoma.