GSDMC and cancer: GSDMD could be used as a prognostic marker in different cancers, including adrenocortical carcinoma, kidney renal clear cell carcinoma, brain lower grade glioma, hepatocellular carcinoma, skin cutaneous melanoma, and rectal adenocarcinoma (19).High GSDMC expression was significantly associated with the tumorigenesis of clear cell renal cell carcinoma (20).