Most genes considered tumor specific in previous studies (tumor suppressor genes: SOCA3, KLF6, and PTGDS [48–50]; tumor enhancer genes: SLC38A2 [51, 52], DUSP1 [53], and FGF7 [54]) were expressed predominantly in tumor stroma or remission stroma than that in pre-treatment tumors (Figure 5A and Supplementary Figure S5B). Here, SLC38A2 is linked to neoplasm.