The most frequently reported grade 3/4 toxicities were fever (11.7 vs. 5.0%, respectively), increased aspartate aminotransferase (AST; 8.3 vs. 5.0%, respectively), hypertension (8.3 vs. 3.3%, respectively), increased alanine aminotransferase (ALT; 6.7 vs. 5.0%, respectively), increased gamma-glutamyl transferase (GGT; 6.7 vs. 6.7%, respectively), pneumonitis (6.7 vs. 1.7%, respectively), and neutropenia (1.7 vs. 6.7%, respectively). The gene discussed is GPT; the disease is hypertensive disorder.