The Asian Cancer Research Group (ACRG) previously performed whole-genome sequencing of GC and divided it into four subtypes: microsatellite instability (MSI); microsatellite stability/epithelial-mesenchymal transition (MSS/EMT); microsatellite stability/TP53 activation (MSS/TP53+) and microsatellite stability/TP53 mutation (MSS/TP53-) (130). Here, TP53 is linked to cancer.