CDKN2A and neoplasm: There is extensive evidence that promoter hypermethylation leads to the silencing of specific tumour suppressor genes in MF/SS including those involved in cell cycle regulation (CDKN2A/2B) (34), DNA repair (MLH1 and MGMT) (35), apoptosis (FAS) (36) and JAK-STAT signalling (SHP-1) (37).