PLCG1 mutations have also been detected in other mature T-cell malignancies, notably HTLV-1 associated ATLL (25), PTCL(NOS) (26), hepato-splenic T-cell lymphomas (27) and AITL (28) with the PLCG1 p.S345F and R48W variants being two of the most frequently reported. Here, PLCG1 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.