MYCN and neuroblastoma: Overexpression of MYCN mRNA in MYCN-amplified NB has an independent function promoting NB cell proliferation through inhibiting the tumor suppressor miRNA let-7: the 3’UTR of MYCN mRNA has multiple binding sites for let-7, and binding of let-7 to MYCN 3’UTR can inhibit let-7 activity (7).