The phosphatidylinositol 3-kinase (PI3K) and its downstream molecule AKT serine/threonine kinase (AKT), have been shown to be closely associated with tumor EMT, and activation of PI3K/AKT leads to the inhibition of epithelial characteristics and expression of mesenchymal proteins (45, 46). The gene discussed is AKT1; the disease is neoplasm.